An immense 40" X 80" cross stitch recreation of the Sistine Chapel took 10 years for Joanna Lopianowski-Roberts to create. Joanna used 1,809 different colour combinations with a total of about 628,296 stitches. She documents the entire process in her self-published book with 45 full colour individual patterns for each scene.

Cross Stitch of Sistine Chapel — Austin Stitchery Guild (via Boingboing)